Tokai Pharma Begins Phase 2 Clinical Trial for its Castration – Resistance Prostate Cancer Drug

December 14, 2012 by  
Filed under Prostate Cancer News

Tokai Pharmaceuticals Inc. is to carry out a clinical study of it castration-resistance prostate cancer drug – Galeterone.

This study is termed the Androgen Receptor Modulation Optimized for Response (ARMOR) 2 trial. Already, the phase 1 clinical trial has revealed that Galeterone was well-tolerated in patients with this form of advanced prostate cancer.

This clinical trial is going to further evaluate Galeterone, which is a proprietary small molecule with potency of disrupting the growth and survival of prostate tumors.

Ira Kantor highlighted details of this new trial which has been published Thursday, December 13, 2012 in the Boston Herald. Details of the post states the following: Cambridge-based Tokai Pharmaceuticals Inc.

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said today it is treating the first patient in the company’s ARMOR2 trial, a clinical study of its lead drug candidate Galeterone, which is designed to treat patients with castration-resistant prostate cancer.

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This is the second study in Tokai’s Androgen Receptor Modulation Optimized for Response clinical development program for the evaluation of Galeterone, a proprietary small molecule, oral drug that disrupts the growth and survival of prostate cancer cells.

Results from the ARMOR1 trial showed that Galeterone had clinical activity and was well-tolerated in patients with CRPC, the company said.

Up to 196 patients, including those who are “treatment-naive” and those who have progressed while taking the androgen-directed hormonal therapy, Zytiga, will be enrolled in the ARMOR2 trial, Tokai said.

The company added Galeterone received fast-track designation from the U.S. Food and Drug Administration this year.

Conclusively, we are going to keep tabs with the developments of this clinical trial, and you would be duly informed of the progress made.

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