The Role Of GABA (Gamma-amino butyric acid) In Prostate Cancer – Causal Or Curative

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There are those who would do anything in order to determine the exact role that GABA plays in the incidence or treatment of prostate cancer. GABA ? gamma-amino butyric acid ? one of the three main amino acids that serve as neurotransmitters in the human body, is with glutamic acid the most abundant neurotransmitter within the central nervous system, and especially abundant and useful in the cerebral cortex, largely responsible for higher brain functions like thought and sensation interpretation.

It would appear actually as though there is a significant expression of GABA, glutamate decarboxylase, and matrix metalloproteinase (MMP) in the prostates of patients with cancer or benign prostatic hypertrophy (BHP), in the prostates of cancer patients with metastasis beyond the gland itself, especially to the lymph nodes, according to suspicions from certain research specialists.

Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that belong to a larger family of proteases known as the metzincin superfamily. Collectively they are capable of degrading all kinds of extracellular matrix proteins while also processing bioactive molecules. They are involved in the cleavage of cell surface receptors, and particularly the release of apoptotic ligands and chemokine stimulation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis and host defense.

Compared to the sparse expression noted in patients without tumor cell metastasis, the heightened expression of GABA and the other chemicals in the bodies of these patients suggested an influence on the production of MMP and on how well prostate cancer cells might be able to invade a person’s system. What was observed in clinical studies was that “GABA stimulation significantly promoted the invasive ability of cancer cells,” while an MMP inhibitor known as GM6001 caused a significant decrease in the same migration.

Research specialists being who they naturally are will never take such an observation at face value, and as such they only suspect that MMP has a causal effect in the invasion of cancer cells caused by the stimulation of gamma-amino butyric acid. However, this much is clear, says they: “increased expression of GABA (appears to) be implicated in cancer metastasis by promoting MMP production in cancer cells,” and they also believe that the GABA receptor pathway may be involved in the process.

‘They’ are Japanese researchers who were looking to see precisely how GABA influenced prostate cancer metastasis, and not only did they find that it did, but they also determined that MMP was very likely its underlying mechanism. What this means to laymen is that something needs to be done about the disease causing or promoting effect the neurotransmitters have on humans? generally speaking. Case in point: prostate condition.

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