Surgery is a better Treatment option for Localized prostate cancer than Radiation Therapy

January 11, 2013 by  
Filed under Prostate Cancer News

Findings from a study on the cost-effectiveness analysis of treatments administered on those with prostate cancer have revealed that surgery is preferred to radiation therapy when it comes to treating localized prostate cancer.

However, it was noted that a combination of brachytherapy and external-beam radiation may be better option when it comes to high risk prostate cancer.

Sally Robertson, a MedwireNews reporter highlighted the details of the study conducted by researchers from University of California San Francisco( UCSF). Excerpts from the post published January, 2013 at the News Medical website reveal the following on the comparative study on the two categories of treatments:

In general, surgery was preferred over RT for men at low risk for disease, whereas combined external-beam radiation therapy and brachytherapy (EBRT+BT) was favorable for men at high risk, report Matthew Cooperberg (UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California, USA) and team.

“Across the risk spectrum, RT was consistently more expensive [than surgical methods],” they add.

The team used a Markov model to follow hypothetical men with low-, intermediate-, and high-risk prostate cancer over their lifetime and after primary treatment. They found that there were significant, but modest, differences in quality-adjusted life years (QALYs) across the treatment options.

Among low-risk patients, those who received three dimensional conformal RT (3DCRT) had the fewest QALYs, compared with those who received BT, EBRT+BT, and intensity-modulated RT.

In contrast, EBRT+BT was the most effective method for intermediate- and high-risk patients.

However, there were no significant differences in QALYs among low-, intermediate-, or high-risk patients across the surgical methods used and, with the exception of EBRT+BT for high-risk disease, surgical alternatives were significantly more effective than RT methods overall.

Furthermore, lifetime costs were statistically and clinically similar across surgical methods among the different risk groups, whereas lifetime costs for RT varied substantially by treatment method across risk strata.

“We believe that through incorporation of both QALYs [quality-adjusted life years] and costs, consistent risk-stratification, inclusion of multiple methods within surgery and RT, and use of lifetime horizon, the present analysis is the most comprehensive economic analysis yet undertaken for this disease,” the researchers say.

Conclusively, from the facts on the above research, it would become interesting to know that effective and efficient treatment methods can now be developed to treat different stages of prostate cancer.

The team in BJU International has concluded that “The findings may inform future policy discussions about strategies to improve efficiency and reduce variation in localized prostate cancer care”.

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