Scientists Identify a Protein that May Cause Aggressive Prostate Cancer

June 1, 2012 by  
Filed under Prostate Cancer News

Researchers from the University of Liverpool are said to have identified a protein that could be responsible for the aggressive prostate cancer in many men. This protein is said to be produced by the PRKCZ gene. Previous researches have linked this gene with advanced or aggressive prostate cancer.

The PRKCZ gene in prostate cells was investigated and it was discovered that a sequence that of protein that is not peculiar with normal proteins were produced by the gene. This sequence was used as a disease maker for the cancerous cells in the prostate. Here are more details about this new discovery:

Scientists have identified a protein that plays a role in causing aggressive prostate cancer; a finding they say could soon lead to new diagnostic tests and treatments for the disease which affects about 16 million men around the world.

Researchers from the University of Liverpool found that the protein is made by the PRKCZ gene, which has previously been shown to play a role in aggressive prostate cancer.

One version of the gene produced a protein only made in prostate cancer cells, according to the scientist who believe it could be used as a disease marker, and provide a potential new target for drug treatment.

“We’ve identified a sequence of the PRKCZ gene in prostate cancer cells that is expressed independently from the normal version, and the protein produced by this gene contains a unique active region,” Prof Chris Foster, who led the study, was quoted as saying by the Daily Mail.

“We now need to discover what role this protein is playing in prostate cancer. If it encourages aggressiveness in the disease then we may be able to develop new drugs that reduce its effects,” Prof Foster said.

Dr Julie Sharp, from the charity Cancer Research UK which owns the British Journal of Cancer, said: “With more than 40,000 men now diagnosed each year with the disease there’s an urgent need to develop tests that tell us how the disease is behaving.

“This research opens a new window on the disease and suggests that versions of this PRKCZ gene could be playing an important role.

“This study highlights how genetically complex cancers are and shows we need to understand and use this knowledge to treat them successfully.”

The study is published in the British Journal of Cancer. Source.

In conclusion, as it was observed in the above extract, the discovery of this protein linking aggressive prostate cancer can lead to new treatments as well as provide a guide for the development to better diagnostic tool for the disease.

This will only mean that the more than 40,000 men diagnosed with prostate cancer will hope to enjoy better treatments of their cases.

Indeed, this new research has opened a new window for the genetic link with prostate cancer. Also, it can help to develop medications that can reduce the effects of aggressive symptoms of the disease.

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