ß4 integrin Protein Could be the Target to Root out Hormone Refractory Prostate Cancer – Study

January 29, 2013 by  
Filed under Prostate Cancer News

A study by researchers of the Memorial Sloan-Kettering Cancer Center in New York has findings that reveals that there are high levels of the ß4 integrin protein are found in advanced, hormone refractory prostate cancer.

When this protein was inhibited in a mouse model, there was inhibition of prostate cancer or tumor in the mouse.

The findings of the study have been published in the Journal of Clinical Investigation as the extract from an online article posted in Science Codex January 27 reveals:

In the Journal of Clinical Investigation, Fillippo Giancotti and colleagues at Memorial Sloan-Kettering Cancer Center in New York, demonstrate that a significant fraction of advanced, hormone refractory prostate cancers express high levels of the protein ß4 integrin.

Using a mouse model of prostate cancer, Giancotti and colleagues found that loss of the ß4 integrin gene significantly inhibited prostate tumor growth and progression by blocking activation of the oncogenic proteins ErbB2 and c-Met, which are responsible for sustaining prostate cancer stem cells.

In a companion commentary Max Wicha of the University of Michigan discusses how targeting of these proteins could be a useful therapeutic strategy for the treatment of advanced prostate cancer.

In conclusion, this could be another significant study that have identified the triggers to advanced prostate cancer.

In humans, if the same result as that experienced with the mouse model applies is validated, then specialists will no doubt can now root out hormone refractory prostate cancer.  You can check out the Journal of Clinical Investigation for more facts on this research.

Below Are Other Related Articles Among 1,000+ Prostate Cancer Articles On
This HUGE 4+ Year Old Prostate Cancer Victory Authority Website:

(95% of these 1,000+ Prostate Cancer Articles on this website
are written by our Expert In -house Writers, after lots of research.
The remaining 5% are news articles and videos from relevant sources!)


  1. How Hormone Refractory Prostate Cancer (HRPC) is Treated
  2. Protein Compositions in Gene Alterations Could Lead To New Discoveries in Drugs And Diagnostic Methods For Prostate Cancer
  3. About New Report on Hormone Refractory (Castration Resistant, Androgen-independent) Prostate Cancer – Pipeline Review H2, 2012″
  4. Study Indicates Cyclin D1b Protein Could Be Biomarker for Prostate Cancer Metastasis
  5. Chemotherapy Prostrate Cancer for Hormone Refractory Metastatic
  6. Cancer Hormone Prostate Refractory and Chemotherapy for Hormonal Refractory Prostate Cancer
  7. EZH2 Protein Increases Hormone Resistant Prostate Cancer and Opens up New Way for Treating Prostate Cancer
  8. Scientists Identify a Protein that May Cause Aggressive Prostate Cancer
  9. Study Suggests Androgen Deprivation May Do More Harm than Good in Men with Prostate Cancer
  10. You Can Survive Aggressive Prostate Cancer With Hormone Therapy And Radiation – New Study Says
  11. Article on Direct Correlation between Advancement of Prostate Cancer and Enzymatic Activity of Integral Mitochondrial Membrane Protein Published
  12. Protein SPDEF in Prostate Cancer Cells Don’t Survive Possible Metastasis Sites
  13. Breakthrough Prostate Cancer Animal Study
  14. Night Shift Increases The Risk of Prostate Cancer – Study
  15. Researchers Discover Protein In Prostate Cancer Cells that Could Help to Determine The Most Suitable Treatment

Speak Your Mind

Tell us what you're thinking... !

s