ß4 integrin Protein Could be the Target to Root out Hormone Refractory Prostate Cancer – Study

January 29, 2013 by  
Filed under Prostate Cancer News

A study by researchers of the Memorial Sloan-Kettering Cancer Center in New York has findings that reveals that there are high levels of the ß4 integrin protein are found in advanced, hormone refractory prostate cancer.

When this protein was inhibited in a mouse model, there was inhibition of prostate cancer or tumor in the mouse.

The findings of the study have been published in the Journal of Clinical Investigation as the extract from an online article posted in Science Codex January 27 reveals:

In the Journal of Clinical Investigation, Fillippo Giancotti and colleagues at Memorial Sloan-Kettering Cancer Center in New York, demonstrate that a significant fraction of advanced, hormone refractory prostate cancers express high levels of the protein ß4 integrin.

Using a mouse model of prostate cancer, Giancotti and colleagues found that loss of the ß4 integrin gene significantly inhibited prostate tumor growth and progression by blocking activation of the oncogenic proteins ErbB2 and c-Met, which are responsible for sustaining prostate cancer stem cells.

In a companion commentary Max Wicha of the University of Michigan discusses how targeting of these proteins could be a useful therapeutic strategy for the treatment of advanced prostate cancer.

In conclusion, this could be another significant study that have identified the triggers to advanced prostate cancer.

In humans, if the same result as that experienced with the mouse model applies is validated, then specialists will no doubt can now root out hormone refractory prostate cancer.  You can check out the Journal of Clinical Investigation for more facts on this research.

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