New Prostate Cancer Vaccine For Treatment

October 4, 2011 by  
Filed under Prostate Cancer News

New Prostate Cancer Vaccine For Treatment:

We just read a news article about a new prostate cancer type vaccine that seems to do a wonderful job of actually searching for and even going ahead to destroy prostate tumor cells.

This really does sound like more good news for the fight against this deadly prostate cancer. Like we always say on this Prostate Cancer website, it’s only a matter of time before we finally have a once-and-for-all solution or treatment for prostate cancer!

See part of the article below:

A two-headed small molecule could marshal a cancer patient’s immune system to seek out and destroy prostate tumor cells (ACS Chem. Biol., DOI: 10.1021/cb200222s). This new immunotherapy strategy also could treat other cancers with few side effects, researchers say.

Prostate cancer cells produce high levels of unique proteins that sit on the cells’ surface, such as the prostate-specific membrane antigen (PSMA). Researchers have targeted these proteins to kill cancer cells by chemically linking PSMA-specific antibodies with chemotherapy drugs or radionuclides. Although the antibodies shuttle most of these toxic agents to cancer cells, the drugs can still hit healthy cells, leading to unpleasant side effects. Also, chemotherapy drugs and radionuclides can be expensive.

DOUBLE DUTY This small molecule consists of DUPA (left end), which can bind to a prostate cancer cell antigen, and DNP (right end), a chemical group recognized by human antibodies. “We wanted to develop a strategy in which a patient’s own immune system, rather than a toxic compound, kills prostate cancer cells,” says David Spiegel, a chemist at Yale University.

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For their so-called chemically induced vaccine strategy, Spiegel and his collaborators, including Peter Schultz at the Scripps Research Institute and Charles Cho at the Genomics Institute of the Novartis Research Foundation, designed an inexpensive molecule that would direct a patient’s immune system to attack only prostate cancer cells.

It consists of two chemical groups linked together: 2-[3-(1, 3-dicarboxypropyl)-ureido]pentanedioic acid (DUPA) and 2,4-dinitrophenyl (DNP). Other researchers have shown that DUPA recognizes and binds to PSMA on the surface of prostate cancer cells (Mol. Pharm., DOI: 10.1021/mp900069d). DNP is used in manufacturing and is a well-known environmental contaminant. For reasons that are unclear, most people already have antibodies against this chemical group. The team speculated that if the DUPA end of the molecule selectively grabbed onto prostate cancer cells, the DNP end would attract these circulating antibodies and trigger an immune response that would destroy the cells. Read the full news article here.

It seems only time will really tell how truly effective this new prostate cancer vaccine will be. But the main point is that scientists in the medical profession and even herbalists are not standing by doing nothing. They seem to be burning their various midnight oils to find a lasting solution to this condition. We are confident that it’s just a matter of time.

So, like we always say – if you have prostate cancer, don’t lose hope. Stay open and keep hoping. And of course, get help immediately. Lots of people have survived the condition, which means you can survive it too, especially with thanks to the many scientists who continue looking for New Prostate Cancer Vaccine For Treatment.

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