Gonax, a Prostate Cancer Medication That Suppresses Testosterone Is Now Approved In Japan

July 3, 2012 by  
Filed under Prostate Cancer News

Astellas Pharma Inc. a Japan-based company that manufactures and sales pharmaceutical products in different parts of the world has now gotten the approval of the Japanese authorities for the marketing of its novel prostate cancer subcutaneous injection known as Gonax.

This drug has the potency of acting as a blocker to the gonadtrophin-releasing hormone (GnRH). Those with prostate cancer can be treated with this medication which several studies and clinical trials have proven it can reduce the level of testosterone in the blood.

More so, Gonax has been certified safe and well tolerated for the treatment of prostate cancer. Below are more facts about this new prostate cancer drug:

Astellas Pharma Inc. (“Astellas”; Tokyo: 4503; President and CEO: Yoshihiko Hatanaka) announced that Gonax® for Subcutaneous Injection (development code: ASP3550, generic name: Degarelix Acetate, “Gonax”) was granted Japanese marketing approval today for the indication of prostate cancer.

Gonax is a gonadtrophin-releasing hormone (GnRH) blocker with a subcutaneously injectable formulation. GnRH is a hormone produced in the hypothalamus in the brain and is involved in the production of the male hormone testosterone thorough binding to the GnRH receptors in the pituitary gland.

Although testosterone is an important hormone that plays a central role in the maintenance of male function, it also stimulates prostate cancer to grow and to spread out and in result, often aggravates symptoms in prostate cancer patients.

Gonax competitively inhibits the binding of GnRH to the GnRH receptors and controls the growth of prostate cancer by suppressing the testosterone production. Based on the results of Phase I and Phase II studies in Japan, Astellas decided to submit the market authorization application by using abroad Phase-III data.

In Phase II studies in Japan and the abroad Phase III studies, Gonax suppressed and maintained the blood testosterone below castration at Day 3, without a testosterone surge which frequently occurs with GnRH agonist treatment. Also, based on the safety results, Gonax appears to be safe and well tolerated.

Gonax has been approved in 59 countries.

In January 2006, Astellas and Ferring Pharmaceuticals (“Ferring”; headquarters: Saint-Prex, Switzerland; Chairman: Frederik Paulsen) entered into a license agreement that gives Astellas exclusive rights to develop and market degarelix for the treatment of prostate cancer in Japan. Since then, Astellas has conducted the development of Gonax in Japan from Phase II. Click here to read the full extract.

The approval of Gonax in  Japan means that people living with prostate cancer can now benefit from the potency of this medication just as other men in 59 other countries have been enjoying.

Suppressing of the male reproductive hormone – androgen or testosterone – has shown great efficacy limiting the stimulation of prostate cancer cells.

Gonax can achieve this, and it does it in a much more safe way for the patient. For more information about this medication, make personal search online using “Gonax” as your keyword.

Finally, if you have prostate cancer, your doctor may or may not recommend this subcutaneous injection as part of your treatment.

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