Connection Between XMRV Virus and Prostate Cancer – The Complete Story

September 22, 2012 by  
Filed under Prostate Cancer News

XMRV virus has been linked with prostate cancer for sometimes now but the association has been controversial among scientists to some extent.

This virus was linked with contamination of the prostate cancer cells samples stored in the laboratory rather than contamination of the prostate cancer patient.

It is important to get full understanding of this the link between this obscure retrovirus and cancer of the prostate. The following is an online extract providing details on the link:

A once-promising discovery linking prostate cancer to an obscure retrovirus derived from mice was the result of an inadvertent laboratory contamination, a forensic analysis of tissue samples and lab experiments – some dating back nearly a decade – has confirmed.

The connection, which scientists have questioned repeatedly over the last couple years, was first proposed more than six years ago, when the telltale signature of the virus, known as XMRV, was detected in genetic material derived from tissue samples taken from men with prostate cancer.

Later studies failed to find the same signature, and researchers reported that while XMRV is a real, previously-undiscovered virus with interesting and useful properties, it is an infection of human prostate cancer cells in laboratories and not of prostate cancer patients.

Now, an analysis by a team of scientists led by researchers from the University of California, San Francisco (UCSF), Cleveland Clinic and Abbott has uncovered the complete story behind this contamination.

As described this week in the open-access journal PLOS ONE, the original association between XMRV and prostate cancer resulted from traces of XMRV that appear to have found their way into the prostate samples from other cells being handled in the same laboratory in 2003. These cells were also contaminated with the retrovirus.

“Everything arose from this presumed contamination event,” said Charles Chiu, MD, PhD, an assistant professor of laboratory medicine at UCSF and director of the UCSF-Abbott Viral Diagnostics and Discovery Center.

Anatomy of a Contamination

XMRV became a focus of research after its genetic signature was first found in prostate cancer samples in 2006. Similar studies in 2009 also detected the virus among samples taken from people with Chronic Fatigue Syndrome – though both discoveries have now been called into question. The original publication related to Chronic Fatigue Syndrome has since been retracted.

When the prostate connection first emerged, there was a lot of excitement in the field, said Chiu, because of the lesson from human papillomavirus, a virus known to cause cervical cancer in women. HPV taught doctors that a cancer caused by a virus could be prevented by giving people a vaccine.

For people with Chronic Fatigue Syndrome, the 2009 news offered hope because it promised new tests that could definitively diagnose their condition – and possibly lead to treatment with antiviral drugs that block XMRV.

But the connection between the virus and both diseases began to unravel after a number of follow-up studies in several different laboratories failed to detect XMRV in tissue samples taken from men with prostate cancer and people with Chronic Fatigue Syndrome. Other studies added to the doubt by providing strong evidence that XMRV may have arisen simply from laboratory contamination.

Working with the original groups that made the 2006 discovery, Chiu and his colleagues sought to definitively uncover how this contamination occurred.

They first repeated the 2006 experiments in an unbiased way by using a variety of methods to examine new samples taken from a cohort of 39 men with prostate cancer. Failing to detect any trace of XMRV in these samples, they went back to the original material described in the 2006 paper and retraced its route through the laboratory step by step.

Quickly, they determined that the virus detected in these samples was essentially identical in each – which suggested contamination rather than natural infection. Viruses like XMRV readily mutate, and if the different men who had donated prostate tissues had truly been infected, there likely would have been more than one strain present. Click here to read the complete story.

With the details provided in the above extract, a better understanding about the XMRV virus and prostate cancer is established. Many details have been revealed and these will help to increase awareness about both.

More importantly, experts are going to use the details provided to carry out further research relating these two factors.The exact cause of prostate cancer is yet to be discovered but this link helps to strengthen further investigation in that respect.

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