Cannabidiol (CBD), a Non- Psychotropic Plant Can inhibits Cancer of the Prostate

May 25, 2012 by  
Filed under Prostate Cancer News

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If Cannabidiol (CBD), which part of the group of non-psychotropic plants or Cannabinoids. is administered to prostate cancer cells, there are high chances that the cancer cells are going to be inhibited.

This is because of the counteractive properties possessed by this plant. This is  the findings of a new research soon to be presented and published in the British Journal of  Pharmacology.

Mostly, they were from Italy and the United Kingdom. The study was carried out by a group of scientists in Europe. Different types of the non-psychotropic  plants were used to arrive at the conclusion: Here are more details:

The administration of non-psychotropic plant cannabinoids, in particular cannabidiol (CBD), inhibit proliferation and selectively trigger cell suicide of prostate carcinoma, according to preclinical data to be published in the British Journal of Pharmacology.

An international team of investigators from Italy and the United Kingdom assessed the anti-cancer properties of various non-psychoactive synthetic and botanical cannabinoids, including CBD, CBG (cannabigerol), CBN (cannabinol) and THCV (tetrahydrocannabivarin), in vivo and in vitro (in culture).

Researchers reported, “The … data presented here allow us to suggest that non-THC cannabinoids, and CBD in particular, retard proliferation and cause apoptosis (programmed cell death) of prostate carcinoma growth via a combination of cannabinoid receptor-independent cellular and molecular mechanisms. … We suggest that non-THC cannabinoids … might provide the basis for the development of novel therapeutic strategies for the treatment of prostate carcinoma.”

Prostate cancer is the second most common cancer in American men. It is the second leading cause of cancer death in American males, trailing only behind lung cancer.

Authors of the study concluded, “[T]he effects reported here, together with previously reported cannabinoid receptor-mediated effects of THC on PCCs (prostate carcinoma cells), might provide momentum to clinical studies on cannabinoids and cannabis extracts as a therapy for human prostate carcinoma, either in addition to currently used treatments, or as stand alones, as suggested also by our present in vivo data.”

A separate study of cannabinoids on prostate cancer published in the present edition of the Indian Journal of Neurology also concluded, “Prostate cancer cells possess increased expression of both cannabinoid 1 and 2 receptors, and stimulation of these results decrease in cell viability, increased apoptosis, and decreased androgen receptor expression and prostate-specific antigen excretion. … It is our conclusion that it would be of interest to conduct clinical trials involving medicinal cannabis or other cannabinoid agonists, comparing clinical markers such as PSA with controls, especially in men with bone metastatic prostate cancer, whom would not only benefit from the possible anti-androgenic effects of cannabinoids but also from analgesia of bone pain, improving quality of life, while reducing narcotic consumption and preventing opioid dependence.”

Cannabinoids and endocannabinoids have been consistently shown to be potent anti-cancer inhibitors in preclinical models, halting the proliferation of glioma cells, breast carcinoma, lung carcinoma, and lymphoma, among other cancer cell lines.

Full text of the study, “Non-THC cannabinoids counteract prostate carcinoma growth in vitro and in vivo: pro-apoptotic effects and underlying mechanisms,” will appear in the British Journal of Pharmacology. Source.

this is new development in the treatment of prostate cancer. A mentioned above, these findings would provide the basis for the development of novel therapeutic strategies against prostate cancer. The study was indeed extensive and it revealed the hidden properties of the Cannabinoids plants.

Prostate cancer or Prostate Carcinoma kills many men in America and it only ranks second after lung cancer as the most dangerous of cancer diseases affecting men. So, findings like that one above is a welcomed to  help save the lives of many currently on the waiting list or death row of prostate cancer.

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