BPH Drug May Delay Progression of Prostate Cancer – Study

November 30, 2012 by  
Filed under Prostate Cancer News

Benign Prostatic Hyperplasia (BPH) is a condition whereby the prostate gland becomes enlarged.

It is common among men who are aging and it is among other health conditions that affect the prostate gland.

With this condition, the man may likely have difficulties in urination; pains while urinating, frequency of urination etc.

One of the novel drugs that have been used and has shown to be effective in treating BPH is Dutasteride.

A recent study has shown that this drug still has effect on prostate cancer patients as it readily help to delay the progression of prostate cancer. More details are provided below:

Dutasteride taken for two years may prevent biochemical progression of prostate cancer (PCa) in men who experience PSA failure after radical therapy, according to a study.

In a double-blind trial, Fritz H. Schröder, MD, of Erasmus Medical Center in Rotterdam, The Netherlands, and colleagues randomly assigned 294 PCa patients who had PSA relapse after radical therapy to receive dutasteride—a dual 5-alpha reductase inhibitor approved for treating benign prostatic hyperplasia—or placebo (147 participants in each study arm). A total of 187 patients (64%) completed 24 months of dutasteride or placebo treatment. Compared with placebo, dutasteride significantly decreased the risk of PSA doubling by 66% for the overall study period, the researchers reported online in European Urology. The drug also significantly delayed disease progression (which included PSA-related and non-PSA-related outcomes) compared with placebo, for an overall relative risk reduction of 59% in favor of dutasteride.

Of the 294 patients enrolled, 107 discontinued treatment prematurely: 71 (48%) in the placebo group, 36 (24%) in the dutasteride group.

The study arms had a similar incidence of adverse events (AEs), serious AEs, and AEs leading to study withdrawal. Investigators were not blinded to PSA levels, which they noted is a study limitation. Source

BPH is related to prostate cancer in some of the symptoms. Urinary difficulties are coming with persons that have BPH as well as those with cancer of the prostate.

Therefore, it is not surprising that this drug can work in some way to treat cancer affecting the prostate gland.

Although the study is not validated, yet it provides new insights and new course of research for investigators and researchers to follow.

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