Bladder Cancer Patients Can benefit from Anti – Androgen Treatment as Prostate Cancer Patients
A new research whose findings were recently published in the Proceeding of the National Academy of Sciences has shown that anti androgen therapy could be beneficial in treating men with bladder cancer.
This conclusion is reached based on the fact that bladder cancer patients diagnosed with high levels of CD24 protein have worse prognoses than those with lower levels of similar expressions of CD24.
More so, high levels of testosterones have been associated with CD24 protein.
The study conducted by researchers from the University of Colorado Cancer Center reveals that using anti- androgen therapy can treat the condition just as in the case with prostate cancer. More details are provided below:
Bladder cancer patients whose tumors express high levels of the protein CD24 have worse prognoses than patients with lower CD24. A University of Colorado Cancer Center study published today in the Proceedings of the National Academy of Sciences shows that CD24 expression may depend on androgens – and that anti-androgen therapies like those currently used to treat prostate cancer may benefit bladder cancer patients.
“This is a major finding – bladder cancer development and spread to other organs depends significantly on CD24, which in turn depends on androgens like testosterone. By taking away these androgens, we may be able to greatly diminish the proliferative and metastatic power of bladder cancer cells,” says the study’s senior author, Dan Theodorescu, MD, PhD, director of the University of Colorado Cancer Center.
Theodorescu and colleagues started with mouse models, showing that mice without the ability to make the protein CD24 had fewer primary bladder tumors and metastases (bladder tumor spread to other organs) compared to mice with CD24 intact. This effect was most marked in male mice. The group moved to human tumor samples, showing that when patients were stratified according to the levels of CD24 expressed in their tumors, especially the male patients had poorer outcomes, including higher rates of relapse and shorter disease-free survival.
“To us, these sex-specific findings implied androgen involvement,” Theodorescu says. Sure enough, when the group knocked down androgen receptors in human bladder cancer cell lines, they saw a corresponding drop in CD24 levels and also decreased cell proliferation. When they artificially added CD24, cell proliferation resumed regardless of androgen levels. In essence, androgen is effectively a hormonal switch that allowed the harmful effect of CD24 to flow.
Together, these finding imply not only a correlative but a causative effect of CD24 – that not only do high levels of CD24 mark more aggressive bladder tumors, but that CD24 in fact drives the aggressiveness of these tumors. While the protein CD24 is difficult to affect directly with current therapies, anti-androgen therapies that would diminish the tumor’s ability to express CD24 are already in wide use for prostate cancer.
“We hope the results of these studies show the rationale for clinical studies of anti-androgen therapies with bladder cancer, especially in those tumors that happen to test markedly high in CD24 expression,” Theodorescu says. “The next step is moving this promising therapy to clinical trials with human patients.” Source.
This study above is quite revealing and it could be helpful also. From the facts above, it implies that the researchers really have done a comprehensive work on the relationship between CD24 and it link with androgen.
Therefore, its not surprising to know that recommending anti-androgen therapy to cure bladder cancer has been proposed.
These therapies can help to diminish the tumors. Thus, further studies on this treatment should be encouraged.
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