http://prostatecancervictory.com/prostate-cancer/cyclopamine-and-prostate-cancer/ Everything You Need To Know To Survive Prostate Cancer Thu, 20 Oct 2011 03:42:24 +0000 hourly 1 http://wordpress.org/?v=3.3 http://prostatecancervictory.com/prostate-cancer/cyclopamine-and-prostate-cancer/comment-page-1/#comment-39 VeratrumC Mon, 11 May 2009 19:08:37 +0000 http://prostatecancervictory.com/?p=202#comment-39 The reason cyclopamine is expensive is because it isn't widely known/used. There is no inherent reason for it's expense. There is no reason to try and synthesize this compound in the US, as it is readily abundant in our corn lily (false Hellbore) plant, although I believe a Chinese group is trying to synthesize cyclopamine from jervine (a closely related compound) because their local variety of Veratrum sp. produces more jervine and less cyclopamine. OUR local Veratrum produces lots and lots of cyclopamine, which is easily extracted and separated from the other sterodial alkloids in the Veratrum root by any of well-known methods. It is unclear to me that a water-soluable analog is required, as subliginual or dermal application of the base may achieve sufficient biopotential to be effective. More research on the bioavailablity/application of cyclopamine base is indicated. The reason cyclopamine is expensive is because it isn’t widely known/used. There is no inherent reason for it’s expense. There is no reason to try and synthesize this compound in the US, as it is readily abundant in our corn lily (false Hellbore) plant, although I believe a Chinese group is trying to synthesize cyclopamine from jervine (a closely related compound) because their local variety of Veratrum sp. produces more jervine and less cyclopamine. OUR local Veratrum produces lots and lots of cyclopamine, which is easily extracted and separated from the other sterodial alkloids in the Veratrum root by any of well-known methods. It is unclear to me that a water-soluable analog is required, as subliginual or dermal application of the base may achieve sufficient biopotential to be effective. More research on the bioavailablity/application of cyclopamine base is indicated.

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