Cyclopamine and Prostate Cancer

Many people are investigating the efficacy or otherwise of Cyclopamine in prostate cancer treatment. I first found out about the power of Cyclopamine from researchers from the University of Texas Medical Branch at Galveston (UTMB). They took the bold step to carry out a demonstration with animals in the laboratory using a compound which was gotten from a kind of common plant. They discovered that this could be useful in the treatment and prevention of even the most widespread kind of cancer in victims. 

After this, they went further to report in October, 2004 in the issue of the Cancer Research that orally administering Cyclopamine can drammatically reduce the development of tumor in mice which are genetically prepared to be prone to skin cancer which is also referred to as basal cell carcinoma (BCC) when they are exposed to ultraviolet light. 

They also showed ample proof that 90% fewer microscopic BCC tumors and 50% fewer visible tumors were noticed after they had treated with Cyclopamine. Conclusively they insist that Cyclopamine has immense clinical promise in the treatment of prostate cancer; hence the search for Cyclopamine prostate cancer treatment by lots of people today. 

If you are wondering what Cyclopamine is and where it is derived from, Cyclopamine is a kind of plant derived from the popular corn lily, a kind of weed plant which grows in mountain meadows, mostly in the Western part of the United States. It’s also a form of alkaloid which is also a very effective inhibitor of the sonic hedgehog-GLI (SHH) thereby helpful in handling different kinds of cancers like lung cancer, breast cancer and prostate cancer. Cyclopamine has been proven to effectively reduce the spreading of cancer cells and also in the promotion of apoptosis in vitro and in vivo. 

The reason why Cyclopamine isn’t widely known and used as a therapeutic agent is mostly because of it’s expensive and difficult ability to synthesize.