Cyclopamine and Prostate Cancer

April 9, 2009 by  
Filed under Prostate Cancer

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Many people are investigating the efficacy or otherwise of Cyclopamine in prostate cancer treatment. I first found out about the power of Cyclopamine from researchers from the University of Texas Medical Branch at Galveston (UTMB). They took the bold step to carry out a demonstration with animals in the laboratory using a compound which was gotten from a kind of common plant. They discovered that this could be useful in the treatment and prevention of even the most widespread kind of cancer in victims. 

After this, they went further to report in October, 2004 in the issue of the Cancer Research that orally administering Cyclopamine can drammatically reduce the development of tumor in mice which are genetically prepared to be prone to skin cancer which is also referred to as basal cell carcinoma (BCC) when they are exposed to ultraviolet light. 

They also showed ample proof that 90% fewer microscopic BCC tumors and 50% fewer visible tumors were noticed after they had treated with Cyclopamine. Conclusively they insist that Cyclopamine has immense clinical promise in the treatment of prostate cancer; hence the search for Cyclopamine prostate cancer treatment by lots of people today. 

If you are wondering what Cyclopamine is and where it is derived from, Cyclopamine is a kind of plant derived from the popular corn lily, a kind of weed plant which grows in mountain meadows, mostly in the Western part of the United States. It’s also a form of alkaloid which is also a very effective inhibitor of the sonic hedgehog-GLI (SHH) thereby helpful in handling different kinds of cancers like lung cancer, breast cancer and prostate cancer. Cyclopamine has been proven to effectively reduce the spreading of cancer cells and also in the promotion of apoptosis in vitro and in vivo. 

The reason why Cyclopamine isn’t widely known and used as a therapeutic agent is mostly because of it’s expensive and difficult ability to synthesize. 

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One Response to “Cyclopamine and Prostate Cancer”
  1. VeratrumC says:

    The reason cyclopamine is expensive is because it isn’t widely known/used. There is no inherent reason for it’s expense. There is no reason to try and synthesize this compound in the US, as it is readily abundant in our corn lily (false Hellbore) plant, although I believe a Chinese group is trying to synthesize cyclopamine from jervine (a closely related compound) because their local variety of Veratrum sp. produces more jervine and less cyclopamine. OUR local Veratrum produces lots and lots of cyclopamine, which is easily extracted and separated from the other sterodial alkloids in the Veratrum root by any of well-known methods. It is unclear to me that a water-soluable analog is required, as subliginual or dermal application of the base may achieve sufficient biopotential to be effective. More research on the bioavailablity/application of cyclopamine base is indicated.

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