Treatment of Advanced Prostate Cancer

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Advanced prostate cancer is when the malignancy of the cells of the prostate gland is no longer just the malignancy of the cells of the prostate gland but a malignancy that is spreading (freely?) through the body with the aid of the bloodstream and the lymphatic system. They don’t mean to help – they are just doing their jobs of sustaining body functions – but the cancerous cells get into these body fluid systems when the tumor has (matured?) in the prostate and is ready to metastasize.

Advanced prostate cancer may be locally advanced, located in the prostate and in the pelvic region. (likely the lymph nodes would be swollen by this time); advanced prostate cancer proper is typically characterized by an extensive spread of the disease to various locations around the body, especially in the skeletal system. Curing the cancer at this time is often out of the question, but treatment may be offered in order to provide palliative care to the patient.

The treatment of advanced prostate cancer therefore is in the interest of delaying the disease’s progression as well as its symptoms, managing bone pain and metastasis, improving the quality of life of the patient, and prolonging his life.

Palliative care does this by focusing on extending life and relieving the symptoms of the metastatic adenocarcinoma. To that effect, some treatments already in use such as hormonal therapy, chemotherapy, and radiation therapy, that can slow disease progression and yes, relieve the symptoms that the patient is suffering from to some degree. However others are needed in order to further improve the outcomes of the treatments.

Abiraterone acetate is one such procedure that is showing some promise in late phase research for treating advanced prostate cancer. The drug causes the PSA levels in a patient to drop dramatically while also reducing the size of a prostate cancer tumor. 70% of the patients with aggressive advanced-stage prostate cancer that were treated with this mediation showed remarkable improvement. Chemo may slow disease progression and postpone symptoms, especially if used with corticosteroids.

Bisphosphonates are ideal for the prevention of fractures in bone metastasis. Zoledronic acid for instance has been shown to delay such skeletal complications and even the need for radiation therapy. It is most applicable then when a patient turns up who has hormone-refractory metastatic prostate cancer, one of the worst forms of the disease. For reducing pain, improving quality of life, and pr prolonged patient survival times, reduced pain and improved quality of life, alpharadin is the new alpha emitting pharmaceutical that will do the trick.

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