Lupron Prostate Cancer – Injections for Treatment

Lupron is a product of leuprorelin or leuprolide acetate, a gonadotropin-releasing hormone agonist (GnRH agonist). Gonadotropin-releasing hormone (GnRH) agonists are synthetic peptides modeled after the hypothalamic neurohormone GnRH that interacts with the gonadotropin-releasing hormone receptor to elicit its biologic response, which is the release of the pituitary hormones FSH and LH.

Prostate cancer is one form of disease that is greatly influenced by the presence of the male hormone testosterone, which quicks morphs into dihydrotestoterone (DHT) in the body once it has gotten into the body. Prostate cancer cells have been long proven to use these hormones as fuels to facilitate their progression in the body, so that one of the accepted treatments for prostate cancer today is intervention by hormonal therapy to suppress the production of the hormones, causing the tumors to regress.

Like other GnRH agonists, lupron is used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, as well as estrogen-dependent conditions, precocious puberty, and to control ovarian stimulation in In Vitro Fertilization. The lupron injection specifically was in fact first approved by the FDA in April 1985 for the treatment of advanced prostate cancer, suggesting an administration of 5 mg/ml for daily subcutaneous injection. Shortly after (1989) the lurpon depot was also approved for palliative treatment of advanced stage prostate cancer; and then derivatives viadur and eligard were approved in 2000 and 2002 respectively also for the palliative treatment of prostate cancer.

It does not take a lot to known that it works, especially with a meticulous agency like the FDA signing off on it so consistently. You should know for a fact that many specialists in prostate cancer treatment do not consider metastatic prostate cancers to be curable to a large degree; as such they offer palliative treatment, especially to older patients who are not expected to have much longer to live, in order to alleviate the symptoms of the disorder and produce a semblance of a normal life. Lupron injections, by depriving the male reproductive system of its testosterone and DHT, cause the progression of the disease to slow and delay the symptoms as is desired.

Sometimes, in the treatment of such late stage prostate cancer, the patient may desire more definitive treatments in order to catch the disease and at least lengthen his life somewhat. To make this happen, immunotherapy and chemotherapy can be considered to boost the body’s immune system to fight the cancer, or to directly attack the malignancies. Sometimes, radiotherapy and even surgery are considered; but often, treatments like those offered by the lupron injection are what make these procedures worth the effort. To be perfectly honest, the prognosis still does not look too good, but what; it’s some kind of guesswork anyway.

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