Bone Metastasis Prostate Cancer – Symptoms And Treatments

Bone metastasis occurs in prostate cancerous tumor when the malignancy grows enough to start to migrate from the organ to other parts of the body. This occurs by means of the cancerous cells filtering into the patient’s bloodstream and then spreading first to the lymphatic system, and then to further out regions of the body, usually ending up at the bones due to some sort of affinity. Such cancerous cells are called metastatic cancer of the prostate cells, and when they are found in the bones, there are referred to as bone metastatic prostate cancer.

Prostate cancer bone metastasis is an occurrence in late stage disease (stage IV), which is considered to be rather problematic at best. The most common bones attacked are the pelvis, the vertebrae, the femur, and the ribs; but it has been known to spread even further away, reaching to the feet, and to the skull. Although there are several medical approaches that can be used to treat the condition, it is not really considered to be curable, for which reason the aim of intervention is more toward palliation than anything else.

Symptoms of bone metastasis of prostate cancer generally involve extensive bone pain, usually in the proximal part of the bone, and then general weakness. It is not often that this happens, but much later indicators of this stage of the disease have tended toward loss of continence and sometimes, even paralysis. This usually occurs when the cancerous cells have gathered in the vertebral column so much that they are starting to compress the spinal cord.

The first step in remedying the situation is to slow the progression of the disease, which is often achieved by hormonal therapy. This requires the surgical removal of the male testicles (orchiectomy) in order to cease its production of testosterone; otherwise drugs are administered orally or intravenously to halt the synthesis of testosterone with dehydroepiandrosterone for cause the body to produce DHT – dihydrotestosterone. In the absence of DHT, prostate cancer cells find it hard to grow and propagate, and they tend to begin to shrink.

In the instance that the cancer is already hormone refractory, another remedy would be chemotherapy, which kills cancer cells, and in this case may also slow its progression. For the bone pain radiation treatments may be administered, or else opioid pain relievers or biosphosphonates will do the trick. To delay the symptoms of the disease, docetaxel and prednisone will work well; and in order to extend life expectancy, it has recently been found that a prostatectomy might just be the key.

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