Prostrate Cancer Treatments Casodex – What you Must Know

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Casodex is the marketing name for Bicalutamide, an oral non-steroidal anti-androgen used in the treatment of prostate cancer and sometimes also hirsutism. The hormonal therapy medication was first launched in 1995 as a combination treatment with surgical (orchiectomy) or medical castration for advanced prostate type of cancer; later it was subsequently approved also as monotherapeutic intervention that could be administered for the treatment of earlier stages of the disease.

Made and marketed by AstraZeneca sometimes also with the brand name Cosudex, the drug is recommended for a 50 mg once daily use. This is often done after the patient has undergone an orchiectomy ? a surgery to have his testicles removed ? or while still undergoing therapy with a luteinizing hormone-releasing hormone analogue.

Casodex works by interrupting the synthesis of dihydrotestosterone (DHT), a hormone produced by the male sex endocrine system to aid with secondary sex characteristics of the man. Unfortunately, this hormone has been found to actually contribute in no small way to the growth of prostate cancer cells because the tumors appear to feed off of it. DHT is produced by the combined action of testosterone from the testicles and dehydrepiandrosterone from the adrenal glands, on the prostate. By removing the testicles, testosterone is no longer available in the body for the creation of DHT, but Casodex further acts to stop the hormone from being created from whatever residues may still be present in the body.

Casodex was approved for the treatment of late stage prostate cancer at first because it was never intended as a cure. As a hormonal intervention for prostate carcinoma, it can only help stop or slow the progression of the disease, and sometimes it can cause tumor to shrink, but this isn’t a cure. After a while, as a matter of fact, the cancer tends to grow resistant to the treatment and resume growth. Therefore the application of Casodex for advanced prostate cancer then was merely a palliative measure.

However, because Casodex is able to help reduce the size of a tumor, use has also been found for it in early stage prostate carcinoma because it can work to shrink the tumor to a size that is more easily operable by the oncologist of urologist when carrying out a prostatectomy. Radiation therapy may also be employed as a follow up, but Casodex at least would have bought the patient some time and some pain relief first of all. Thankfully, it has a close to negligible effect on the sexual activity of most male patient’s treatment by it in the early stages of prostate cancer.

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