Lupron Prostate Cancer – How Lupron Can Help You

Lupron is the American trade name of a GnRH agonist whose real chemical tag is leuprolide. Other GnRH agonists that function in the same category include goserelin, triptorelin, and buserelin. If you want to read more about depot lupron for prostate cancer, keep reading.

GnRH refers to the gonadotropin-releasing hormone, which is responsible in the male endocrine system for stimulating the pituitary gland to produce luteinizing hormone. The luteinizing hormone, or LH, stimulates the male testicles to produce testosterone, which in turn works with dehydroepiandrosterone from the adrenal glands to stimulate the prostate gland to produce dihydotestosterone (DHT). DHT is a metabolite that often triggers the swelling of the prostate and has been implicated as a promoting agent in the proliferation of prostate cancer cells as they spread from the prostate to other (remote) parts of the body.

GnRH agonists have been investigated for their connection to birth control options for men and women, but more importantly for their ability to impede the production of DHT in prostate cancer treatment. Lupron is one such drug, which is administered in the form of an injection. It acts to prevent the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland, which, in turn, blocks spermatogenesis (the development of sperm) in men. The way lupron works however is agonizes the body to increase the production of LH; yet because the body is not able to sustain the heightened level of LH production due to the constant supply of the medication, production of both LH and GnRH crashes after only a couple of weeks, and the prostate cancer cells that depend on them for progression and metastasis start to slow in growth and even shrink.

Lupron injections for prostate cancer are getting a lot more popular in the United States for the treatment of the condition because they generally are not as invasive as other treatments like radiotherapy or prostatectomy. However, they are limited in the regard that as hormonal treatments, they often don’t cure the cancer, which often causes them to have to be applied in order to slow progression and reverse tumor growth so that other interventions can be applied to cure the disease.

Hormonal treatments are best applied in the instance of advanced prostate cancer in men who are not responding adequately to treatment by surgery or radiation. Often, they can help in late stage palliative care as well to delay symptoms and prolong life. Using Lupron for prostate cancer, specifically Lupron injections, are however one of the most successful hormonal treatments in the medical community, even though they are more expensive than the alternative – orchiectomy. As for the side effects of lupron shots in men for prostate cancer, that’s a topic for another day.

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