Leukine And Prostate Cancer

Leukine is the marketing name for a recombinant granulocyte macrophage colony stimulating factor (GM-CSF). The actual name of the product is sargramostim, which is marketed by Bayer in the United States. Leukine functions as an immunostimulator, which in the treatment of certain diseases is desirable to boost the body’s immune system in order to combat disease. Leukine in particular is produced in yeast.

Ordinarily, Leukine, or sargramostim, is used for myeloid reconstitution after autologous or allogeneic bone marrow transplantation. By way of explanation, after a bone marrow transplant, the patient is immunologically vulnerable for a while during which the body absorbs the new transplant and adjusts to it. In order to speed up the healing process, Luekine is administered to the patient. The drug has also found use in the treatment of neutropenia induced by chemotherapy during the treatment of acute myeloid leukemia.

Most recently however, it has been found that Leukine is also therapeutic against certain forms of cancer, with a specific focus on prostate cancer. Usually, once a patient has been diagnosed with prostate cancer, the first objective might be to stop the cancer from growing, even cause it to shrink.

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To do this, it customary to employ some form hormonal therapy which may not work for certain tumor types. This discovery determines that Luekine is effective against this kind of hormone refractory (resistant) prostate cancer cells.

As a matter of fact, it was also determined that all GM-CSF substances were active products that help the body’s immune system in dealing with biological threats, however their published results specifically state that Leukine has been “used by itself and in combination with other drugs in chemotherapy trials of non-chemo therapies” to good use. In that wise, Leukine stands out as some kind immunotherapeutic drug that is best applied in the instance of rising PSA in a patient that has already undergone a previous treatment like prostatectomy or radiation, or a particularly stubborn manifestation of prostate cancer that appears to be resistant to other therapies.

There are pointers that you should be aware of though, while use a drug like sargramostim. For starters, it ought not to be used by patients with excessive leukemic myeloid blasts in the bone marrow or peripheral blood. In addition, patients with known hypersensitivity to GM-CSF, or yeast-derived products, or any component of the product, should steer clear. If the doctor prescribes it, let them know that you are allergic, or else?

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