Estrogen Injections For Prostate Cancer

Harold Burrows and E. S. Horning first summarized the effects of estrogens in large and continuous doses in their British Medical Bulletin release of 1947). Then the use of estrogens in large quantities was merely shown to produce fibromyomatous changes in the uteri of rabbits and guinea pigs, and also to cause similar changes in the human uterus. It was also shown then that occasionally a carcinoma of the cervix or body of the uterus occurs in the human female after the prolonged use of such estrogenic materials.

One deduction from those tests was that it would probably be found in a short time that the administration of large quantities of estrogens might possibly induce breast cancers in human beings because sex hormones also possess the capacity of inducing certain nonspecific types of cancer. Even then, there is a realization that carcinomas of the prostate showed remarkable temporary remissions, albeit without cures when administered estrogen injections.

But that was so a hundred years ago! Today, estrogen therapy is very actively used in the hormonal treatment for prostate cancer; one particular estrogen, estradiol, is even suspected of being hugely remedial for treating the disorder.

Generally speaking, hormonal therapy for prostate kind of cancer patients is based on what is now the sound fact that prostate cancer cells frequently use the male hormone, testosterone, as something of a “fertilizer” to spur their growth. As a consequence of this it is not only presumed but it has also been proven by large bodies of experiments that the absence of testosterone leads to the apoptosis of most prostate disease cells. Although not all of the this cancerous tumor cells are weakened or killed in this way, but at least patients with incurable prostate condition in the late stages can now have their lives extended and its quality improved through these hormone treatments.

At one time the removal of the testicles was the only hormonal therapy treatment for late stage prostate cancer, and is still remains the most cost effective one today. However, several injectable medicines, LHRH agonists, (Lupron, Zoladex, Eligard, Viadur, Trelstar or Vantas), and LHRH antagonists, (Plenaxis) that block the production of testosterone by the testes have now sprung out of the results of various researches. Given at varying intervals from one month to a year, depending on the drug and dosage, they are longer acting, usually more expensive, and may be discontinued for a period of time with little or no delayed return of testosterone levels.

Estrogen injections for prostate cancer are the most perfect examples, because these female hormones not only suppress the production of testosterone but also have a negative effect on this cancerous tumor cells. As a matter of fact, they can be used in cases of hormone resistant cancer of the prostate , or as early therapy in the initial stages. Although high dose estrogens appear to cause increased blood clotting, DES (diethylstilbestrol), a synthetic estrogen, is used in low dose in patients with hormone resistant prostate cancer.

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