Chemotherapy Prostrate Cancer for Hormone Refractory Metastatic

It doesn’t get much worse than that when you have prostate cancer. At the onset of the disease, you hardly feel anything, even as the cells mutate and begin to grow inside of you. Give it a while, and you start to feel the pain that should never have been there if you had been able to catch the disease on time, say by going in for a medical checkup in a hurry, getting the disease diagnosed, staged, and the right combination of treatments applied to it. However, if you missed catching a stage one prostate cancer, and you somehow got to the point where you have all of this pain in urination and in sexual intercourse, sometimes seeing blood, you have to subject yourself to some kind of aggressive treatment for the disease.

Stages III and IV of prostate cancer advancement are a problem that even the doctors are never in a hurry to get to. At this point, the problem is chiefly that the mutated prostate gland cells have spread all through your body to the bones of your back, pelvis and hips, thigh, and ribs. Certainly, you could be feeling symptoms of lymphoma as well, as the carcinoma pervades and degrades your lymph nodes too. As a last ditch effort, some doctors will recommend that you allow yourself to be subject to any complex combination of treatments which would likely include prostatectomy, hormonal therapy, and certainly some form of radiation therapy.

Advanced stage prostate cancer is often referred to also as hormone-refractory metastatic. This implies that the disease has spread to several areas of your body and it is difficult to catch at best, and also that the cancerous tumors are now stubborn, aggressive, rebellious, and uncontrollable by any form of hormone action. At some stage, they could have used hormonal therapy to starve the cancers to death, but now it’s too late. Now, palliative care is probably your best option, in which the doctors focus not on healing or curing your condition, but on extending your life and relieving you of the symptoms of the metastatic disease.

There are some cases in which doctors are still able to administer chemotherapy for this type of suffering. However, you should know that this hormone-refractory metastatic prostate cancer is not particularly considered to be effectively treatable, and the chemo is mostly only to slow disease progression and postpone symptoms. Often the physician combines a certain drug docetaxel with a corticosteroid like prednisone. Also, they may apply some zoledronic acid to delay any skeletal complications that may surface, like fractures and such.

Another drug, Abiraterone Acetate, has been shown to deliver some promise in treating this kind of advance stage prostate cancer, causing a dramatic reduction in prostate specific androgen levels. Chemotherapy for hormonal refractory prostate cancer will produce some of the needed relief? but in the minds of the doctors, only long enough for the patient to pass on.

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