P53 Nfkb In Prostate Cancer – Low-Fat High-Fiber Diet And Exercise

Men who are undergoing a low-fat, high-fiber diet in conjunction with exercise intervention have been shown to produce a serum which decreases the growth of prostate cancer cells, and increases their chances of apoptosis, especially for the kinds of prostate type of cancer (LNCaP) that are stimulated by serum and dependent on the androgen hormone levels in the male body. As such, certain researches have been carried out in order to determine precisely what underlying mechanisms have made these anticancer effects a possibility.

During the course of clinical trials, it was found that the Insulin-Like Growth Hormone-1 (IGF-1), when added back to the post-intervention samples, caused the responses to be eliminated; which also resulted in the p53 protein content being increased and NFkB activation reduced in post serum-stimulated LNCaP cells. When the IGF-I receptor was blocked in the pre-intervention serum, similar results were observed; and it was found that in androgen-independent prostate kind of cancer stage 3 (PC-3) cells, growth was reduced while none of the other factors were changed by the intervention.

Leaving all the jargons out of the mix, what the research determined was that diet and exercise intervention, although not entirely confirmed, definitely has a negative effect on prostate form of cancer, and actually might help prevent the clinical condition.

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In addition, doctors who had prescribed such in the past as a therapeutic approach to dealing with prostate condition in patients were not wrong, especially for carcinomas observed during the early stages of development.

The p53 protein in prostate cancer cells is a factor that is used in the detection of the disease in certain diagnostic efforts. As a matter of fact, the mutation of the p53 gene is the most common genetic alteration in all human cancers, mutant p53 proteins being more stable than wild type p53, and also detectable by immunohistology. Today, it is believed that the mutation of the p53 gene plays a critical role in curing the disease, with its reactivity marking an aggressive subset of prostate cancer that appears to be an independent prognostic indicator that is particularly valuable among the low to intermediate grade cancers.

NF-?B plays a key role in regulating the immune response to infection. Consistent with this role, incorrect regulation of NF-?B has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. The invasion by NF-kB mediated downstream target genes is therefore something that needs to be regulated in much the same vein as the migration of prostate tumor cells because NF-kB is now a therapeutic target for prostate condition. As such, to make this happen doctors these days prescribe treatment for prostate cancer patients by asking them to take diets rich in fiber, and exercise a lot to improve blood flow and anti-carcinogenic processes in men.

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