If you want to information about abiraterone prostate cancer then you could be trying to get facts about abiraterone. This is a drug that is used to treat advanced metastatic prostate cancer.
It was developed in the UK and has been approved by in the US by the FDA. There are some interesting facts you really should know about this drug and these are highlighted below.
Abiraterone is also known as Zytiga, Abiraterone Acetate, or CB7630.It comes in tablet form and is taken once in a day in combination of steroid like prednisone. The aim of the steroid is to inhibit inflammation of cells. Zytiga is used to treat men who have prostate cancer that is termed metastatic.
Metastatic prostate cancer is the type of prostate cancer that has spread beyond the confines of the prostate gland. The first line of treatment for this stage of cancer is the administration of hormone therapy. This is treatment procedure administered to block androgen or testosterone in the body. The reason for administering hormone therapy is based on the discovery that testosterone stimulates the growth of prostate cancer.
At some point in time some of the hormonal treatments used may no longer be effective to treat prostate cancer, then need for second line medications like Abiraterone becomes necessary.
The use for abiraterone in treating cancer of the prostate
Abiraterone is used a second line hormonal treatment for prostate cancer that has resisted first line treatments. In other words, this medication can help to treat castration-resistant prostate cancer or hormone-refractory prostate cancer. Thus, when prostate cancer is no longer responding to androgen blockers, abiraterone can be introduced by the doctor.
It works by blocking an enzyme called cytochrome P17 (CYP17) which stimulates the production of the androgen or testosterone in the body. Also for men who had undergone chemotherapy treatments using Docetaxel, Abiraterone could be used as a re-treatment option.
The effectiveness of abiraterone in prostate cancer
Several studies have shown the effectiveness of abiraterone as a treatment for prostate cancer. In a clinical trial, it was discovered increase the average survival rates of men by four months. The report of the study was published in the New England Journal of Medicine on May 26, 2011.
Finally, in the UK, the National Institute for Health and Clinical Excellence (NICE) had early banned abiraterone as part of the treatments issued on the National Health Service (NHS). This decision was based on cost factors. However, public outcries, NICE rescinded its decision after the manufacturer has discounted the cost.
You can consult with your doctor for more information on abiraterone prostate cancer.
Prostate cancer treatments are more often than not administered depending on the type of cancer, the stage and the physical disposition of the patient.
One of the most popular treatments administered to prostate cancer patients is chemotherapy. This treatment is usually applied to patients with advanced, bone metastatic or hormone refractory cancer.
It can be applied independently or in combination with other medications such as surgery, radiation therapy, or Cryotherapy.
Chemotherapy is applied in small but frequent doses. It could be introduced into the body as injections or as oral medications. In some cases, the doctor may use a venous device access to introduce the medications right through veins of the patients so that the fastest action can take place. This machine is placed on top of the skin and tubes from it connect to the vein where the medication passes through. You can find out more information about this chemotherapy device from your doctor.
The following are some of the chemotherapy drugs that have been approved or that can be used by doctor to treat advanced cancer of the prostate:
- Estramustine Phosphate (Emcyt) – This is a drug that comes as capsules. It is taken orally one or two hours before meals. You can take it with water or with dairy products. Estramustine Phosphate is an alkylating agent.
- Doxorubin (Adriamycin) – This a medication administered as intravenous. It has the potency of inhibiting protein production and works by binding the DNA of the cell. However, care is always taken when administering this drug because if it escapes from the brain, it can result to swelling around the injection site, redness and severe pain.
- Mitoxantrone (Novantrone) - this medication is administered in the form of injection. It is one of the groups of chemotherapy drugs called antineoplastics. When combined with other drugs like prednisone, it helps to treat inflammation of cells.
- Other popular chemotherapy drugs you may want to know include Vinorelbine, Carboplatin, Doxetaxel, and Etoposide (VP-16).
The side effects of chemotherapy drugs
Just as most treatment come with side effects, chemotherapy drugs also come with their own complications. The side effects of chemotherapy drugs could be dangerous and they may include impotence and incontinence, pains, redness, hair loss, skin irritation, etc.
Conclusively, the above are just brief hints on types of drugs administered to patients that have been diagnosed with prostate cancer. These drugs highlighted above are chemotherapy drugs and they come with some side effects. You should talk to your doctor about the risks and benefit of using any of the above listed medications.
The research for prostate cancer is still on going. Most especially as the exact reason why cancer develops in humans is yet to be identified. Many drugs have been developed over the years to treat this condition that is affecting about 1 in 6 men. Before the approval of most these drugs, clinical trials are conducted by the pharmaceutical Companies.
If you are not in the know, or that you want to know something about clinical trials for prostate cancer drugs, this article can be a source of enlightenment for you. Read on for more details on these trials.
What is a clinical trial?
The meaning of clinical trial is simply a study which aims to test the effectiveness of a new drug to be introduced for use by patient suffering from a particular illness. This study or experiment is conducted under the supervision of an authorized health body. In the United States, most clinical trials for the development of new drugs are supervised and approved by the Food and Drugs Administration (FDA).
Prostate Cancer Clinical Trials
When a new drug for the treatment of prostate cancer is developed, the pharmaceutical company may carryout a clinical trial to determine the safety and effectiveness of the drug on patients who have been diagnosed with prostate cancer. This type of cancer originates from the tissues of the prostate gland and could spread to other parts of the body slowly.
Volunteers (who are mostly patients of prostate cancer) are tested with new drug. The procedure applied in the trials is systematic and carefully applied to ensure the safety of the volunteers. In the course of the trial, evaluations and conclusions are reached on the safety and possible side effects of the new investigational drugs.
The importance of prostate cancer clinical trials
The importance of clinical trials for prostate cancer cannot be underestimated even though many patients are skeptical of volunteering for the trial. It is possible for patients to get treated effectively of their condition. More so, it provides them with opportunity of being the first partaker of the drug that could be very useful in the future. In addition, the treatment offered to most patients during clinical trials is more carefully done and could be more effective than those done ordinarily.
Finally, prostate cancer clinical trials in the United States are supervised by the FDA. So, if you have been reluctant about being a volunteer, then this news could be moral booster for you. Major pharmaceutical companies you can think of, at one time or the other, conducts these trials on new drugs they intend to offer to the public. So, if you have the chance of participating in a clinical trial, go ahead.